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KMID : 1123920030170041013
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Korean Journal of Oriental Physiology and Pathology
2003 Volume.17 No. 4 p.1013 ~ p.1018
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The Mechanism Study of Cheonghunhwadam-tang Gamypang on the Regional Cerebral Blood Flow and Mean Arterial Blood Pressure in Rats(IV)
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Jung Hyun-Woo
Kim Cheon-Joong
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Abstract
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Cheonghunhwadam-tang(CHT) have been used in oriental medicine for many centuries as a therapeutic agent of vertigo by wind, fire and phlegm. CTG was CHT adding Aurantii FructusㆍGastrodae Rhizoma. CTG was significantly increased regional cerebral blood f1ow(rCBF) in a dose-dependent, and CTG was decreased mean arterial blood pressure(MABP) compared with normal MABP(100%) in a low dosage, but was increased MABP in a dose-dependent, was aliked with normal MABP in a high-dosage. Therefore, purpose of this Study was to investigate experimental mechanism of CHTAG on the cerebral hemodynamics(rCBF, MABP) in rats. The changes of rCBF and MABP were determinated by Laser-Doppler Flowmetry(LDF). The results were as follows ; Pretreatment with indomethacin(3㎎/㎏, i.v.) was significantly inhibited CTG induced increase of rCBF and pretreated with propranolol(3㎎/㎏, i.v.) was inhibited CTG induced increase of rCBF, but pretreatment with methylene blue(10㎍/㎏, i.v) was increased CTG induced increase of rCBF. Pretreatment with indomethacin was decreased CTG induced increase of MABP, but pretreatment with propranolol and methylene blue were increased CTG induced increase of MABP. This results suggest that the mechanism of CTG is mediated by cyclooxygenase.
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KEYWORD
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Cheonghunhwadam-tang(淸暈化痰湯加味方), regional cerebral blood flow, BP, Laser-Doppler Flowmetry, cyclooxygenase
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